GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptide
GAPVD1
Reactivité: Humain
Hôte: Synthetic
BP, IHC, WB
N° du produit ABIN977276
Aperçu rapide pour GTPase Activating Protein and VPS9 Domains 1 (GAPVD1) Peptide (ABIN977276)
Antigène
GAPVD1
(GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-GAPVD1 antibody (Catalog #: ARP42451_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GAPVD1 (GTPase Activating Protein and VPS9 Domains 1 (GAPVD1))
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Sujet
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GAPVD1 acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. It acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. It is also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. It has GEF activity for Rab5 and GAP activity for Ras.
Alias Symbols: DKFZP434C212, KIAA1521, MGC138847, MGC138848, RAP6, GAPEX5
Protein Interaction Partner: YWHAB,CBL
Protein Size: 1487 -
Poids moléculaire
- 166 kDa
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ID gène
- 26130
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NCBI Accession
- NM_015635, NP_056450
Antigène
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